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Therapeutic Area Head -- Cardiovascular and Renal Disease CVMED - Full-time / Part-time
•30 days ago
| Hours | Full-time, Part-time |
|---|---|
| Location | Cambridge, Massachusetts |
About this job
Org Marketing Statement
All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. Each position at Pfizer touches and contributes to the success of our business and our world. That's why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed to seeking out inspired new talent who share our core values and mission of making the world a healthier place.
Role Description
The leader of the Therapeutic Area unit will be responsible for directing a program in the development of therapies for Cardiovascular and Renal diseases from early exploratory biology through positive Proof-of-Concept (POC). The successful candidate will be a driver of innovation and scientific excellence, identifying and advancing the best novel therapeutic hypotheses, targets and molecules. This experienced scientist will be expected to develop a Division within CVMED recognized as a leader in its field by driving and responding to rapidly breaking science and evolving global healthcare demands. Programs from this department will help position the Pfizer Cardiovascular and Renal portfolio as one of the most valuable and innovative pipelines across the industry.
* Lead a Therapeutic Area program within the Cardiovascular and Metabolic Diseases (CVMED) Research Unit, being responsible for identifying novel targets or pathways to treat atherosclerosis, heart failure and diabetic nephropathy and cardiorenal diseases
* Partner with other disciplines of integrated drug discovery and development, especially chemistry, pharmacokinetics and drug disposition, and clinical, to build a pipeline of clinical candidates with strong and clear rationale for differentiation from standard of care; deliver highly competitive, positive "Proof of Concepts" that fulfill product models aligned to a carefully formulated therapeutic strategy.
* Identify and unite emerging science with unmet medical needs. Drive and prosecute a balanced and innovative therapeutic area portfolio of small molecule and biologic based targets, critically prioritized based on rigorous and innovative science.
* Advance programs by the most effective means to test hypotheses and therapeutics convincingly and safely in humans.
* Serve as a role model to Pfizer colleagues by maintaining the highest standards of scientific rigor and ethical principals. Nurture a culture that promotes challenging and respectful interactions among Pfizer colleagues and their external consultants and collaborators.
Passionately and positively strive for the discovery of new cardiovascular medicines.
Responsibilities
Strategy:
Set priorities aligned with and integrated into the strategic direction of the RU; serve as a single point of accountability for the delivery of the therapeutic area portfolio from target ID to candidate.
Direct and inspire a team of scientists in the identification of potential targets, the development of small molecules and biologic therapeutics, and basic and clinical discovery research in related scientific areas.
Partner with Clinical members of the business unit to deliver differentiated and innovative medicines through to positive proof of concept (POC).
Work in collaboration with the CVMED CSO to define strategies to identify breakthrough medicines for Cardiovascular and Renal disease.
Collaborate with key internal and external biomedical scientists to drive improved understanding of disease pathophysiology to deliver a highly competitive and innovative drug discovery portfolio.
Set objectives for the therapeutic area to generate an appropriate return on investment.
Influence the global external environment through a visible presence in the academic scientific community and active engagement with key opinion leaders
Foster a collaborative and productive environment between Pfizer CVMED RU and academic biomedical researchers.
Portfolio:
Deliver a sustainable, highly competitive pipeline from target-to-POC.
Ensure scientific strategy for each drug discovery project is rigorous, aligned and effective.
Interface with senior PharmTx and BioTX leaders to balance risk with opportunity, and exploit the full repertoire of therapeutic modalities.
Prepare reports and presentations as needed describing the progress and strategy of the Cardiovascular/Renal unit in CVMED
Management:
Ensure all activities executed comply with legal and regulatory requirements and with Pfizer corporate policies.
Supervise and assume responsibility for a team of scientists devoted to the development of cardiovascular and renal drugs.
Build an "intelligence" capability and external network of biomedical research collaborations and advisors to find the most attractive therapeutic mechanisms.
Ensure projects are adequately resourced and prioritized to deliver on objectives, and manage the associated budget.
Eliminate barriers and silos that inhibit collaboration across departments and line functions and foster a culture of open collaboration, communication and transparency.
Communication:
Clearly communicate and articulate the vision and strategy to stakeholders and regularly report on portfolio progress.
Inspire, model, and reinforce colleague expectations to urgently create value with an appropriate return on investment, apply innovative, rigorous science to discovering new medicines, accept individual and collective accountability for value creation, and continuously improve organizational effectiveness.
Build a cohort of colleagues with the quality of scientific leadership and external recognition to generate competitive advantage in attracting the best talent and collaborators.
Engender a high level of engagement across both direct and indirect lines.
Attract and grow highly effective scientists and drug discoverers and nurture a culture that translates breaking biological science into new medicines more effectively than the competition.
Effectively, rigorously and accurately review and develop talent. Proactively address development needs and make difficult decisions when appropriate.
Qualifications
Preferred Training & Education:
* M.D., Ph.D., or M.D./Ph.D.
* Deep working knowledge of medical practice, diseases and biology relevant to Cardiovascular Disease.
* Knowledge of competitive landscape for therapeutic area.
Preferred Prior Experience:
* >5 years experience as an independent investigator directing a team of scientists in high quality cardiovascular research
* Recognized deep biological expertise and record of innovative research in cardiovascular physiology and disease.
* Established national and international scientific reputation
* Demonstrated track record of high impact publications
* Record of team leadership and active, productive collaboration
Technical Skills Requirements:
Scientific leader in his or her field as demonstrated by highly cited publications, editorials appointments and presentations at top-level scientific meetings
A compelling and inspiring research scientist with a sharp scientific mind, who combines broad knowledge and understanding of biological systems with world-class leadership skills.
Decision making and problem solving profile that enables marrying emerging science with unmet medical need to identify potential breakthrough medicines.
The ability to assimilate new information, achieve expertise in novel disciplines and greatly expand his or her scope of knowledge and understanding.
Combines knowledge from multiple sources to generate novel and high impact ideas. Gets to the core of the problem, asks insightful and probing questions and progresses to the next step effectively.
Strategically and rigorously assess projects in light of overall pipeline strategy and quickly and decisively advances or terminates projects.
Disaggregates complex problems to facilitate problem solving.
Business "mindset" that teases out and understands risks inherent in drug discovery (small molecule and biotherapeutic), and makes decisions appropriate to opportunity and required investment.
Thinks laterally, connecting seemingly unrelated data, information, perspectives etc, at people, scientific and business levels.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. Each position at Pfizer touches and contributes to the success of our business and our world. That's why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed to seeking out inspired new talent who share our core values and mission of making the world a healthier place.
Role Description
The leader of the Therapeutic Area unit will be responsible for directing a program in the development of therapies for Cardiovascular and Renal diseases from early exploratory biology through positive Proof-of-Concept (POC). The successful candidate will be a driver of innovation and scientific excellence, identifying and advancing the best novel therapeutic hypotheses, targets and molecules. This experienced scientist will be expected to develop a Division within CVMED recognized as a leader in its field by driving and responding to rapidly breaking science and evolving global healthcare demands. Programs from this department will help position the Pfizer Cardiovascular and Renal portfolio as one of the most valuable and innovative pipelines across the industry.
* Lead a Therapeutic Area program within the Cardiovascular and Metabolic Diseases (CVMED) Research Unit, being responsible for identifying novel targets or pathways to treat atherosclerosis, heart failure and diabetic nephropathy and cardiorenal diseases
* Partner with other disciplines of integrated drug discovery and development, especially chemistry, pharmacokinetics and drug disposition, and clinical, to build a pipeline of clinical candidates with strong and clear rationale for differentiation from standard of care; deliver highly competitive, positive "Proof of Concepts" that fulfill product models aligned to a carefully formulated therapeutic strategy.
* Identify and unite emerging science with unmet medical needs. Drive and prosecute a balanced and innovative therapeutic area portfolio of small molecule and biologic based targets, critically prioritized based on rigorous and innovative science.
* Advance programs by the most effective means to test hypotheses and therapeutics convincingly and safely in humans.
* Serve as a role model to Pfizer colleagues by maintaining the highest standards of scientific rigor and ethical principals. Nurture a culture that promotes challenging and respectful interactions among Pfizer colleagues and their external consultants and collaborators.
Passionately and positively strive for the discovery of new cardiovascular medicines.
Responsibilities
Strategy:
Set priorities aligned with and integrated into the strategic direction of the RU; serve as a single point of accountability for the delivery of the therapeutic area portfolio from target ID to candidate.
Direct and inspire a team of scientists in the identification of potential targets, the development of small molecules and biologic therapeutics, and basic and clinical discovery research in related scientific areas.
Partner with Clinical members of the business unit to deliver differentiated and innovative medicines through to positive proof of concept (POC).
Work in collaboration with the CVMED CSO to define strategies to identify breakthrough medicines for Cardiovascular and Renal disease.
Collaborate with key internal and external biomedical scientists to drive improved understanding of disease pathophysiology to deliver a highly competitive and innovative drug discovery portfolio.
Set objectives for the therapeutic area to generate an appropriate return on investment.
Influence the global external environment through a visible presence in the academic scientific community and active engagement with key opinion leaders
Foster a collaborative and productive environment between Pfizer CVMED RU and academic biomedical researchers.
Portfolio:
Deliver a sustainable, highly competitive pipeline from target-to-POC.
Ensure scientific strategy for each drug discovery project is rigorous, aligned and effective.
Interface with senior PharmTx and BioTX leaders to balance risk with opportunity, and exploit the full repertoire of therapeutic modalities.
Prepare reports and presentations as needed describing the progress and strategy of the Cardiovascular/Renal unit in CVMED
Management:
Ensure all activities executed comply with legal and regulatory requirements and with Pfizer corporate policies.
Supervise and assume responsibility for a team of scientists devoted to the development of cardiovascular and renal drugs.
Build an "intelligence" capability and external network of biomedical research collaborations and advisors to find the most attractive therapeutic mechanisms.
Ensure projects are adequately resourced and prioritized to deliver on objectives, and manage the associated budget.
Eliminate barriers and silos that inhibit collaboration across departments and line functions and foster a culture of open collaboration, communication and transparency.
Communication:
Clearly communicate and articulate the vision and strategy to stakeholders and regularly report on portfolio progress.
Inspire, model, and reinforce colleague expectations to urgently create value with an appropriate return on investment, apply innovative, rigorous science to discovering new medicines, accept individual and collective accountability for value creation, and continuously improve organizational effectiveness.
Build a cohort of colleagues with the quality of scientific leadership and external recognition to generate competitive advantage in attracting the best talent and collaborators.
Engender a high level of engagement across both direct and indirect lines.
Attract and grow highly effective scientists and drug discoverers and nurture a culture that translates breaking biological science into new medicines more effectively than the competition.
Effectively, rigorously and accurately review and develop talent. Proactively address development needs and make difficult decisions when appropriate.
Qualifications
Preferred Training & Education:
* M.D., Ph.D., or M.D./Ph.D.
* Deep working knowledge of medical practice, diseases and biology relevant to Cardiovascular Disease.
* Knowledge of competitive landscape for therapeutic area.
Preferred Prior Experience:
* >5 years experience as an independent investigator directing a team of scientists in high quality cardiovascular research
* Recognized deep biological expertise and record of innovative research in cardiovascular physiology and disease.
* Established national and international scientific reputation
* Demonstrated track record of high impact publications
* Record of team leadership and active, productive collaboration
Technical Skills Requirements:
Scientific leader in his or her field as demonstrated by highly cited publications, editorials appointments and presentations at top-level scientific meetings
A compelling and inspiring research scientist with a sharp scientific mind, who combines broad knowledge and understanding of biological systems with world-class leadership skills.
Decision making and problem solving profile that enables marrying emerging science with unmet medical need to identify potential breakthrough medicines.
The ability to assimilate new information, achieve expertise in novel disciplines and greatly expand his or her scope of knowledge and understanding.
Combines knowledge from multiple sources to generate novel and high impact ideas. Gets to the core of the problem, asks insightful and probing questions and progresses to the next step effectively.
Strategically and rigorously assess projects in light of overall pipeline strategy and quickly and decisively advances or terminates projects.
Disaggregates complex problems to facilitate problem solving.
Business "mindset" that teases out and understands risks inherent in drug discovery (small molecule and biotherapeutic), and makes decisions appropriate to opportunity and required investment.
Thinks laterally, connecting seemingly unrelated data, information, perspectives etc, at people, scientific and business levels.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.