Reverse Translational Senior Scientist - Full-time / Part-time

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Job DescriptionAbout the role:

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission.

Takeda is committed to outsmarting cancer so that more patients may have access to our transformational medicines – a robust precision and translational medicine approach thoughtfully and strategically applied in drug development is of critical importance to achieving this important objective of our Oncology drug development organization.

Reverse Translation is an important capability we recently created to extract maximum value from our clinical studies and other clinical-facing data to inform our early pipeline in oncology and cell therapy. The Reverse Translation Scientist role is an exciting new role within the Precision & Translational Medicine (PTM) function in the Oncology Therapeutic Area Unit (OTAU) at Takeda. 

As a Reverse Translation Scientific leader in Oncology Precision & Translational Medicine (PTM), you will provide scientific leadership and research planning to maximize the utilization of human and clinical study data to inform and accelerate the discovery and development of new drug candidates in Oncology and Cell Therapy in the preclinical and clinical stages. This is a matrixed role, responsible for partnering with the Oncology Drug Discovery Unit (ODDU), scientific leaders in Precision & Translational Medicine, Global Product Teams, physician-scientists, and scientific project teams to inform and support drug development strategy, target identification and validation, patient selection, Go/No-Go inflection points and business opportunities.

This role reports to the Reverse Translation Development Lead in PTM and works closely with functional line leadership to develop reverse translational and biomarker plans as part of Takeda's Asset Strategies through all stages of clinical development.

How you will contribute:

• Partner with Oncology DDU discovery research, Redirected Immunity programs, and physician-scientists in designing and executing Reverse Translational research to inform and accelerate assets in early drug development, helping de-risk clinical development and increase the probability of success.  
• Lead Reverse Translational Biomarker strategy development and execution to inform Takeda's pre-clinical space and evolving pipeline, business opportunities, differentiation of assets, repurposing opportunities, and internal and external partnership opportunities.
• Lead timely execution of reverse translation & biomarker plans to inform program decisions with internal and external collaborators via working as a part of successful multidisciplinary teams.
• Participate in oncology disease area strategy development as needed.
• Represent Reverse Translation on assigned project teams in Oncology and Cell Therapy. Provide strategic, technical, and scientific leadership for the progression of programs from discovery research to clinical development and contribute as a subject-matter expert for overall asset strategies as needed.
• Establish and drive key external collaborations, and maintain a scientific dialog with external thought leaders and clinical translational experts in medical, academic, and regulatory communities in support of reverse translational strategies and activities.
• Maintain extensive knowledge of the research and development efforts from academic institutions and competitor biopharmaceutical companies; stay up to date with the literature.
• Manage the preparation and review of the Reverse Translation Research Plan. Evaluate and use state-of-the-art scientific tools and ensure the implementation of cutting-edge technologies to drive innovation in the execution of the Reverse Translation strategy.
• Interphase with leadership, report on project progress and address emerging needs. Author study reports.
• Support Business Development efforts by evaluating potential in-licensing opportunities and serve as a liaison with external partners, organizations, consultants, and university representatives.

Minimum Requirements/Qualifications:

• Ph.D. degree in a scientific discipline.
• At least 5 years of experience in translational biomarker research.
• Experience in Oncology and/or Cell Therapy translational research.
• Experience in AML/ NSCLC/ CRC malignancies preferred.
• Recognized expertise in biomarker discovery and development and translational medicine as demonstrated by publications, and presentations in leading meetings.
• Experience in drug discovery and/or development.
• Excellent communication skills (written and oral).
• Strong leadership abilities and proven ability to lead a team within a matrix organization as well as to work independently.

Takeda is proud of its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

WHAT TAKEDA CAN OFFER YOU:

• 401(k) with company match and Annual Retirement Contribution Plan
• Tuition reimbursement is a company match of charitable contributions
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• Community Outreach Programs

Base Salary Range: 130200.00 to 186,000.00 Employees may also be eligible for Short-Term and Long-Term Incentive benefits. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program, and Paid Volunteer Time Off. 

The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time