Principal Investigator

Opportunity: Principal Investigator (General Medicine)

Metric Bio is partnering with a high-performing and rapidly expanding clinical site network based in Massachusetts, in the search for an accomplished Principal Investigator specialising in General Medicine. This is a unique opportunity to lead meaningful clinical research, drive innovation, and directly impact patient outcomes within a cutting-edge US-based organisation.

The Role:

As the Principal Investigator, you will provide expert medical leadership across multiple clinical trials, ensuring scientific integrity, regulatory compliance, and the highest standards of patient safety. You’ll be a key contributor in shaping research strategy, guiding clinical teams, and building strong collaborations with sponsors and stakeholders.

Key Responsibilities

• Serve as the lead Principal Investigator across general medicine clinical trials
• Oversee all aspects of study conduct, ensuring alignment with protocol, GCP, and FDA standards
• Conduct medical evaluations, determine eligibility, and monitor patient safety
• Provide expert input into feasibility assessments and study design
• Safeguard data quality and ethical integrity across trials
• Develop and maintain strong sponsor and regulator relationships
• Mentor and support Sub-Investigators and research teams
• Champion clinical excellence and continuous process improvement

Required Qualifications & Experience

• MD/DO with active and unrestricted US medical license.
• Minimum 5 years’ post-licensure experience in general or internal medicine
• Direct involvement in 10 or more clinical trials (Phase II–IV preferred) as Principal Investigator or Sub-Investigator.
• Deep understanding of GCP, FDA regulations, ICH guidelines, and clinical governance
• Proven track record in clinical leadership and decision-making
• Excellent communication, patient-centric approach, and collaborative mindset

What’s on Offer

• Competitive compensation package + comprehensive benefits
• Opportunity to lead high-impact trials across varied therapeutic areas
• Innovative, collaborative research environment
• Professional development & leadership support
• Make a significant contribution to improving future patient care

Interested in Applying?

If you are an experienced physician with a passion for research leadership and meet the clinical trial experience requirement, we would love to hear from you.

Contact Metric Bio: oli.oldham@metric-search.com