Principal Investigator / LCMS Scientist

Senior / Principal LC-MS Scientist

Columbia, Missouri (on-site)

Relocation assistance available

We are searching for a Senior / Principal LC-MS Scientist to join a growing bioanalytical team in Columbia, MO. This is a hands-on role within a GLP-regulated environment, supporting bioanalytical studies from method development through reporting. The team is continuing to build, so this role is best suited for someone who is comfortable working independently and taking ownership of their work.

What you’ll be doing

• Develop, validate, and execute LC-MS methods for bioanalytical studies
• Analyze biological samples (plasma, tissue, etc.) using LC-MS/MS systems
• Interpret data and prepare clear, accurate reports for clients
• Participate in client communications, including study updates and data discussions
• Ensure adherence to GLP standards and regulatory requirements
• Review study data and documentation for accuracy and completeness
• Troubleshoot technical issues and identify opportunities for improvement
• Support instrument calibration, maintenance, and optimization (Shimadzu, SCIEX, or similar)
• Collaborate with internal scientific, regulatory, and operational teams

What we’re looking for

• Bachelor’s degree or higher in Chemistry, Biology, or related field
• NO LESS THAN 3+ years of hands-on LC-MS experience (more for Principal level)
• Direct experience working in a GLP environment (required)
• Strong understanding of method development, validation, and sample analysis
• Ability to manage multiple studies and meet timelines
• Strong communication skills

Nice to have

• Experience in a CRO setting
• Prior team lead or mentoring experience
• Exposure to client-facing work
• Experience with Shimadzu, SCIEX, or similar platforms
• Experience with Watson or similar systems

Additional insight

This is not a highly structured, task-by-task role. The team is still building, and the right candidate will be someone who can work autonomously, take initiative, and operate effectively without needing day-to-day direction.