Scientist I ADME

Responsibilities

Scientific Responsibilities

• Design, execute, and interpret a range of in vitro ADME/DMPK studies, including:
• Metabolic stability
• Reaction phenotyping
• Metabolite identification
• CYP inhibition and induction
• Transporter studies
• Plasma protein binding
• Solubility and permeability assays
• Analyze and interpret complex scientific datasets.
• Prepare study reports, data summaries, and client presentations.
• Troubleshoot technical challenges and recommend scientifically sound solutions.
• Contribute to assay development, validation, and continuous improvement initiatives.
• Ensure studies are conducted in accordance with client requirements and applicable quality standards.

Client and Project Responsibilities

• Serve as a scientific point of contact for assigned client programs.
• Participate in project kickoff meetings, study updates, and scientific discussions with clients.
• Provide technical input during proposal development and study scoping activities.
• Support Business Development teams by participating in scientific and capabilities presentations.
• Build strong client relationships through scientific excellence and responsive communication.

Quality and Compliance

• Maintain accurate laboratory records and documentation.
• Ensure compliance with GLP, GCP, GMP, and internal quality systems as applicable.
• Support client audits, regulatory inspections, and quality investigations.
• Promote a culture of scientific integrity, quality, and continuous improvement.

Success Measures

• Deliver high-quality, scientifically robust ADME data on time.
• Build strong relationships with clients and internal stakeholders.
• Contribute to repeat business through technical expertise and exceptional customer service.
• Support growth of the ADME business through innovation, scientific leadership, and operational excellence.

Skills, Education & Qualifications

Required

• M.S. with 3+ years of relevant industry experience; Pharmaceutical Sciences, Drug Metabolism, Biochemistry, Chemistry, or related field with 0-3 years of relevant experience; or
• B.S. with 5+ years of relevant industry experience.
• Experience conducting in vitro ADME or DMPK studies.
• Experience within a Contract Research Organization (CRO) environment.
• Strong understanding of drug metabolism, pharmacokinetics, and drug-drug interaction assessment.
• Experience with LC-MS/MS data interpretation.
• Excellent verbal and written communication skills.
• Demonstrated ability to manage multiple projects simultaneously.

Preferred

• Experience in metabolite identification (MetID).
• Knowledge of regulatory guidance related to DMPK studies.
• Experience supporting pharmaceutical and biotechnology clients.
• Familiarity with software such as MassHunter, Analyst, Phoenix WinNonlin, MetabolitePilot, or equivalent.
• Previous client-facing experience.
• Experience contributing to business development activities or proposal generation.