Scientist II

Position Title: Scientist II
Work Location: South San Francisco, CA 94080
Assignment Duration: 12 Months
Work Arrangement: 100% Onsite

Position Summary:
Discovery Biotherapeutics and Genetic Medicine at our organization is seeking a highly motivated research scientist to join a dynamic team supporting biologics drug discovery and engineering. The successful candidate will be responsible for the design and execution of in vitro display technologies for lead antibody identification, optimization, and will collaborate with other team members to generate stage-gate appropriate in vitro and in vivo data packages supporting proof-of-concept (PoC).

Key Responsibilities:
* Responsible for the design and execution of in vitro display technologies for lead antibody identification, optimization
* Collaborate with other team members to generate stage-gate appropriate in vitro and in vivo data packages supporting proof-of-concept (PoC)
* Leverage scientific expertise to develop and implement research supporting the discovery, optimization, and mechanistic understanding of the molecular pharmacology of therapeutic molecules across Therapeutic Areas
* Analyze, document, and report data effectively
Qualification & Experience:
* Education: BS or MS in Biology or a related field with typically 5+ years of experience (BS) or 2+ years of experience (MS) in a pharmaceutical and/or relevant research environment
* Hands-on experience with in vitro antibody discovery display technologies (e.g., phage display, yeast display)
* Direct experience with binding assays (e.g., ELISA, flow cytometry or SPR)
* Strong molecular and cell biology skills (e.g., molecular cloning, sequence analysis, E coli and/or yeast culture, mammalian cell culture, etc.)
* Familiarity with protein structure, affinity, antibodies and antibody fragments

Preferred Skills & Experience:
* Experience in antibody engineering and optimization (e.g., affinity modulation, liability engineering, humanization)
* Experience with antibody library design and construction
* Experience in mammalian cell culture and multiplex flow cytometry
* Experience with automation of biologics discovery processes
* Proficiency with Prism, Geneious and/or Genedata
* Excellent oral and written communication skills, including proficiency with MS Office Suite (Excel, PowerPoint, Word)