Senior Associate Scientist

Job Title: Senior Associate Scientist
Location/Site: Cambridge, MA, 02140
Duration of Assignment: 12 months
Work Schedule: Mon- Fri (100% Onsite)

Description:
Biomedicine Design's Endogenous Antibody Discovery Group is seeking a Senior Associate Scientist to support antibody discovery projects focused on B cell-based workflows. This role will contribute to therapeutic antibody discovery campaigns using rodent immunization, serum titer screening, B cell sorting by flow cytometry, immune library generation, and hybridoma-based methods. The successful candidate will execute established laboratory workflows that support immunization-based discovery, including rodent selection, immunization strategies (protein, cell-based, and genetic), serum response evaluation by ELISA, flow cytometry, VH/VL molecular cloning, immune library generation and quality control, electrofusion, and hybridoma culture and screening. The role will also contribute to the evaluation and implementation of new technologies that enhance immunization and flow cytometry-based antibody discovery workflows in collaboration with other group members.

The successful candidate should bring hands-on experience and technical capability in several of the following areas, aligned with the responsibilities of the role:

• Hands-on experience supporting antibody discovery workflows, including flow cytometry, B cell-based methods, or hybridoma-based screening.
• Working knowledge of molecular biology techniques such as PCR, cloning, and immune library generation or related sample preparation workflows.
• Experience with laboratory documentation, data organization, and communicating experimental results clearly to project teams.
• Strong laboratory organization skills, including reagent handling, inventory support, and maintaining materials needed for experimental workflows.

Responsibilities:

• Provide laboratory support for therapeutic antibody discovery campaigns using flow cytometry, immune library generation, and hybridoma-based methods.
• Execute established workflows to support rodent immunization studies, serum titer screening, B cell sorting, molecular cloning, and related sample processing activities.
• Maintain reagent inventories, prepare laboratory materials, and ensure operational readiness for discovery activities.
• Document experimental procedures, results, and observations accurately in laboratory records and internal data systems.
• Summarize data and communicate key findings, experimental progress, and campaign outcomes to project teams.

Nice-to-have skills:

• Experience with flow cytometry-based analysis or cell sorting.
• Experience with laboratory automation or high-throughput workflows.
• Experience working with rodents, particularly mice, in a research setting.
• Experience working with hybridoma generation, culture, or screening workflows.

Qualifications:

• Bachelor's degree in biology, immunology, molecular biology, biochemistry, or a related scientific discipline, with at least 2 years of full-time laboratory experience in an academic or industry setting.