Associate Research Scientist Contractor, RNAi Formulations

Job Title: Associate Research Scientist Contractor, RNAi Formulations
Location: Lexington - MA
Duration: 1 year
Reporting Expectations: Onsite; Monday to Friday, 8:00 AM to 5:00 PM
Payrate: $35- $39/ hr. on W2
 
Top 3 skills:
1. Lab experience in formulation of oligonucleoProducts or antibodies for subcutaneous injection
2. Hands on analytical characterization of oligonucleoProducts or antibodies/protein
3. Experience with developability assessments, including evaluation of parameters like maximum solubility, viscosity, osmolality, limited chemical, and physical stability
 
Job description:

• The Associate Research Scientist Contractor, RNAi Formulations, will be based within Non-Viral Delivery (NVD) in Research & Early Development. This is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleotide Product delivery activities for injectable therapeutics.

Relationships:

• Reports to the US Team Manager for Nucleic Acid Delivery, Formulations and Bioanalysis. Interacts closely with peers and cross-functional partners specializing in non-viral delivery, formulation development, oligonucleotide Products chemistry, stability assays, PK, bioanalysis, Client, and external collaborators.

Essential Functions:

• Support the development and characterization of preclinical RNAi and oligonucleoProducts formulations across portfolio and platform projects.
• Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
• Establish and run screening assays for oligonucleoProducts in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments.
• Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
• Support long-term storage and stability evaluations for RNAi conjugates and oligonucleoProducts formulations.
• Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
• Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
• Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
• Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.

Qualifications And Skills:

• MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleoProducts delivery, or a related discipline.
• Hands-on experience with oligonucleoProducts or antibodies/proteins formulation and characterization is strongly preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other developability assessments for complex oligonucleoProducts or antibody/protein formulations.
• Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions.
• Awareness of external trends and advances in RNA delivery, oligonucleoProducts therapeutics, and clinical translation is a plus.
• A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.

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