Scientist

Job Description:

• Support the development of in vivo CAR-T platforms from concept through preclinical development.

• Work at the intersection of synthetic biology and immune modulation.

• The role includes designing CAR constructs, executing advanced cell-based assays and collaborating with cross-functional teams to generate high-quality data that support pipeline programs.

• Apply subject matter expertise in T cell and synthetic biology approaches toward the development of the next-generation in vivo CAR-T cell therapies, and the ability to translate evolving scientific and intellectual property insights into impactful therapeutic programs.

• Independently establish, track, and deliver on project milestones and experimental timelines, ensuring alignment with program objectives and organizational priorities, while adapting to evolving scientific needs.

• Design and execute in vitro assays to evaluate CAR-T biology, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.

• Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports.

• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).

Qualifications:

• BS, or equivalent education, with typically 7 or more years of experience; OR

• MS, or equivalent education, with typically 5 or more years of experience; OR

• PhD level with experience in CAR-T, genetic medicine, or immuno-oncology.

• Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions.

• Proven capacity to quickly learn and apply new laboratory techniques.

• Able to manage multiple tasks efficiently while meeting deadlines.

• Strong skills in scientific writing and verbal communication.

• Expertise in CAR-T biology, T-cell functional assays, and therapeutic development.

• Extensive experience in assay development for CAR-T candidate generation and assessment

• Previous experience in chimeric antigen receptor (CAR) construct design, CAR-T production, and T cell function evaluation.

• Deep expertise in primary T cell isolation, activation, transduction, T cell cytotoxicity, proliferation, cytokine profiling, multi-color flow cytometry, and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.

• Previous experience in leading preclinical cell therapy projects and mentoring scientists will be a plus

• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is a plus.

California Fair Chance Act:

Synectics Inc. will consider qualified applicants with a criminal history pursuant to the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if Synectics Inc. is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report. Find out more about the Fair Chance Act by visiting calcivilrights.ca.gov/fair-chance-act/.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first of the month following at least 1 calendar year after employment begins.

Synectics is an equal opportunity employer.

Synectics is a leading staffing and workforce solutions company dedicated to connecting exceptional talent with top organizations. We specialize in IT, engineering, finance, healthcare, and professional services recruitment, offering both contract and permanent staffing solutions. With a people-first approach, we focus on understanding the unique needs of our clients and candidates to create long-term, successful matches. Our mission is to empower businesses with the right talent while helping professionals achieve rewarding career opportunities