Biologist II

·         The ADC (Antibody Drug Conjugates) platform group within SMTPT (Small Molecule Therapeutics & Platform Technologies. 

·         ADC Platform group collaborates with drug discovery project teams across all Company therapeutic areas including Oncology and Immunology. 

·         The ideal candidate will effectively work to collaborate with chemists, biologists and pharmacologists to characterize large and small molecules for ADC development. 

Key Responsibilities: 

·         Design and execute in vitro assays for screening of biologics, small molecules and antibody drug conjugates 

·         Reporter, cytokine release, cell killing and antibody internalization assays 

·         Generate and characterize transient and stable cell lines to support antibody drug conjugate programs. 

·         Lipid transfection and lenti viral infections 

·         Characterize lead molecules and confirm mechanism of action 

·         Work collaboratively  with project teams to deliver targets across portfolio  

·         Demonstrate scientific excellence, work ethic, and dedication to team and project goals 

·         Work collaboratively in a matrix with project teams and members of the Biologics Group to drive innovation and deliver novel therapies to patients 

·         Develop productive collaborations and communication with other groups across therapeutic areas 

Basic Qualifications: 

·         Bachelor’s degree in related discipline with 3 or more years of experience and a BS in Biology or Biochemistry 

·         Experienced screening antibodies, small molecules and siRNAs (reporter assays, proliferation and cytokine release)   

·         Experience executing antibody internalization and siRNA loss of function studies is a plus 

·         Experience with transfections and generating transient and stable cell lines 

·         Experience culturing adherent, suspension and primary cells 

·         Proficiency in performing flow cytometry and western blot experiments 

·         Experience with performing qPCR and automated western blot analysis 

·         Experience working with high throughput laboratory workflows and instruments such MACsQuant, FACS Canto, Microbeta, Wes, Amnis Imagestream, Via7 (taqman) and Spectramax plate readers. 

·         Experience documenting experimental methods and results into BIOELN 

·         Ability to summarize and present results to project teams 
 

Years of experience/education and/or certifications required:  

·         Bachelor’s degree in related discipline with 3 or more years of experience and a BS in Biology or Biochemistry 
 

What are the top 3-5 skills requirements should this person have? 

·         Cell Culture/In Vitro cell biology work 

·         Lab experience 

What is a nice to have (but not required) regarding skills, requirements, experience, education, or certification?  

·         Small molecule screening experience