Sr Associate Scientist, in vivo Pharmacology - IBD

About Sonoma Biotherapeutics
Sonoma Biotherapeutics is a South San Francisco- and Seattle-based company leading the development of adoptive Treg cell therapies for autoimmune and degenerative diseases. Using next-generation genome editing and target-specific cell therapy, Sonoma is focused on developing its best-in-class platform across the entire spectrum of Treg cell therapeutic capabilities. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies. More information at www.sonomabio.com .

Position Summary:

We are seeking a hardworking, enthusiastic Associate Scientist / Senior Associate Scientist to support the in vivo Pharmacology group to help build the best-in-class regulatory T cell therapies for autoimmune diseases. The ideal candidate will have extensive experience conducting in vivo studies in mouse models of autoimmunity, inflammatory diseases and / or cancer to test the functionality of CAR-Treg cells. Extensive experience working with rodents (mice / rats) is a must. The successful candidate will demonstrate the ability to carry out independent and cross-functional teamwork, demonstrate creativity and apply critical thinking, help develop new pharmacology models and protocols, and generate reproducible, high-quality data to inform and support the development of Sonoma Biotherapeutics’ next generation CAR-T cell therapy programs. 

Roles and Responsibilities:

• Conduct in vivo experiments to assess functionality of engineered regulatory T cell candidates
• Conduct in vitro experiments to analyze cells ex vivo by flow cytometry, ELISA, IHC etc.
• Organize and manage daily operations in Sonoma’s vivarium
• Collaborate with team leaders, scientists and peers to design, execute and troubleshoot studies
• Highly organized with diligent and detailed documentation of experimental procedures
• Generate, analyze, interpret, and present data to project teams and research staff

Qualification and Education Requirements:

• Bachelor’s degree or higher in life sciences such as immunology, cell biology or a related field.
• 6+ years (Senior Associate Scientist) of relevant with hands-on in vivo experience
• Strong scientific understanding and logical thinking are required.
• Excellent verbal and written communication skills with the ability to analyze and present data and write reports efficiently.

• Proficiency in data analysis using Prism, Excel and flow cytometry analysis software is strongly preferred.

• Agile mindset and comfortable in a rapid-moving team and highly productive team environment.

Preferred Skills:

• Experience with in vivo mouse models of inflammatory bowel disease (IBD) is strongly preferred.
• Highly proficient in mouse handling and injections/administration (ip, iv, sc, po)
• Isolation of cells from mouse gut tissue for phenotypic and functional analysis
• Experience in in vitro and ex vivo techniques (e.g, Multi-color flow cytometry, ELISA)
• Experience with primary cells isolation and culture
• Dedicated to maintaining high laboratory standards with regard to safety and quality
• Must be able to understand, conduct, and interpret results of technically challenging experiments with minimal supervision

A day in the life:

The day-to-day life of a team member of the in vivo Pharmacology Team is executing in vivo studies for pipeline programs and discovery projects. As a member of the IVP team, you will have the opportunity to contribute to mouse model development to build novel, reliable and reproducible disease-relevant models that will be essential to make critical decisions to support and advance pipeline programs. You will be a critical team member wor king on IND-enabling studies directly contributing to move Sonoma Bio’s drug candidates into the clinic.

Sonoma Biotherapeutics is an Equal Opportunity Employer

At Sonoma Biotherapeutics, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Sonoma Biotherapeutics is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply. Please submit your resume along with a cover letter to careers@sonomabio.com resumes may also be submitted without applying for a specific job.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at careers@sonomabio.com.