Associate Scientist II, Process Development - Upstream

About Forge

Our mission at Forge Biologics, is to enable access to life changing gene therapies and help bring them from idea into reality. We partner with innovators in the gene therapy community: scientists, physicians, biotech/pharma companies, and patient groups. We bring expertise in gene therapy manufacturing and therapeutics development to the table, helping to champion teams that are navigating the long road from the lab bench to the bedside. Our goal is simple but vital to patients living with disease, and we take it seriously. With a patient-first approach, we are forging new models for working together to better accelerate these transformative medicines to reach those who need them the most. 

Forge is based in Columbus, Ohio, in a 200,000 square foot facility known affectionately by team members as, the Hearth. The Hearth, is a custom-designed cGMP facility dedicated to AAV manufacturing and hosts scalable, end-to-end manufacturing services.

About The Team

The Upstream Process Development Department is responsible for designing and optimizing the production processes of Adeno-Associated Virus (AAV) vectors, which are essential components in gene therapy treatments. The team focuses on developing scalable and robust upstream processes that enable efficient and high-yield production of AAV vectors. They conduct research and apply advanced techniques to enhance vector yield, quality, and purity, while also ensuring compliance with regulatory guidelines.

About The Role

The Associate Scientist II, Process Development – Upstream plays a critical role in supporting the development and optimization of AAV manufacturing processes. This individual will closely with cross-functional teams to lead and execute experiments, collect and analyze data, and contribute to the overall development of scalable AAV production processes.

What You'll Do

• Lead the design, planning and execution of experiments for AAV upstream process development.
• Independently operate and troubleshoot bioreactors and other upstream equipment.
• Optimize cell culture and transfection processes to improve AAV yields and quality.
• Analyze and interpret complex experimental data, identifying trends, and suggesting improvements.
• Assist in the training and guidance of new team members.
• Develop and revise standard operating procedures (SOPs) and batch records.
• Assist in maintaining proper inventories of raw materials and consumables.
• Prepares formulations and raw materials as specified in protocols without the introduction of contaminants.
• Collaborate with cross-functional teams to transfer and scale up processes for manufacturing.
• Participate in equipment maintenance and calibration activities

What You'll Bring

• Bachelor's Degree in Chemical Engineering, Biomedical Engineering, Biology, or related discipline (or equivalent experience).
• Working knowledge of cell culture techniques utilizing mammalian, insect, or microbial cells.
• Prior suspension cell culture experience utilizing shake flasks or bioreactors.
• Experience conducting and compiling experimental data with minimal oversight.

Work Environment and Physical Demands

This position works in both a laboratory environment and typical office environment where the physical work demands will vary depending on the specific tasks and duties required of the job. The employee will be stationary (standing/sitting) for extended periods of time. Employees regularly wear personal protective equipment based on the task being performed. Must be able to work in a confined space, such as a clean room or laboratory environment. Ability to identify small details within the field of vision, distinguish between different colors, and accurately identify objects within a specific area.

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change or new ones may be assigned.

Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce. Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Life at Forge

We are a team of diverse, driven and passionate people working together to trailblaze a new model for how we make medicines to treat patients with genetic diseases. Our team members use their creativity and talent to invent new solutions, meet new demands, and offer the most effective services in the industry. Forge's core values lay the foundation for H.O.P.E. It provides us a common purpose that we all understand, work towards and live by. 

HARDWORKING - We work hard and smart, making a persistent and determined effort toward success. Working hard, with focus and desire is the key.

OPEN - We strive to be approachable, actively listen and encourage others to contribute and speak up. We positively offer and receive constructive feedback.

PURPOSE DRIVEN - We are passionate about working towards and delivering on our mission to manufacture gene therapies.

ENGAGED - We are fully absorbed by and enthusiastic about our work and take positive action to further Forge's vision, mission and goals.

We've Got You Covered

We take the health and happiness of our employees seriously and are consistently evaluating new ways to make our benefits truly UnFORGEttable.

• Health, Dental, and Vision insurance that starts on your first day at Forge, with 90% of premiums covered for team members as well as dependents
• Flexible PTO (plus 14 paid company holidays)
• Annual bonus for all full-time employees

• 401(K) company match
• Fully-stocked kitchen with free food/drinks
• 12 weeks of paid parental leave - additional discount programs include childcare support & dependent care
• Employee Assistance Program
• Wellness benefits (financial planning services, mental health counseling, employer paid disability)
• Professional & Personal development resources - LinkedIn Learning, a dedicate training staff in-house, mentoring opportunities & access to leadership development coaches